| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, ISO 9001, USP, BP |
| Suitable for: | Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Pharmaceutical Grade Antihypertensive Drugs Amlodipine Maleate Powder CAS 88150-47-4 Best Price Amlodipine Maleate
| Product name: Amlodipine maleate |
| Other Name: Norvasc |
| Appearance:White powder |
| CAS:88150-47-4 |
| M.F.:C24H29ClN2O9 |
| M.W.:524.948 |
| Specification:99% |
Amlodipine Maleate is the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug response activity through inhibition of the p-glycoprotein efflux pump.
| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Used for treatment of various types of hypertension (alone or in conjunction with other agents) and angina pectoris, especially with spontaneous angina pectoris (alone or with other drugs in combination). This product has a protective effect on kidney.
1. Hypertension. It can be used alone or in combination with other antihypertensive drugs.
2. Chronic stable angina and variant angina. This product can be used alone or in combination with other anti-angina pectoris drugs.
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