| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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API Raw Artesunate Powder Best Price Artesunate Antimalarial
| Product name: Artesunate Powder |
| Other Name: Artesunate Hcl |
| Appearance:White Powder |
| CAS:88495-63-0 |
| M.F:C19H28O8 |
| M.W.:384.42 |
| Specification:99% |
Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection. According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over quinine as the treatment of choice for falciparum malaria. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. As base/solvent, sodium bicarbonate and catalyst DMAP have been used, with yields of up to 100%. A large scale process involves treatment of DHA with a mixture, a catalytic amount of DMAP and succinic anhydride. The mixture is stirred for 6-9 h to get artesunate in quantitative yield. The product is further re-crystallized. alpha-Artesunate is exclusively formed (m.p 135-137C).
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
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