| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, ISO 9001, USP, BP |
| Suitable for: | Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Botanical Resource:. Scphora japonica L
Part of the Plant Used: Flower bud
Molecular Formula: C27H30O16
Molecular Weight: 610.517
CAS No. : 153-18-4
Molecular Structure:
Appearance & Color: Yellow to greenish yellow powder
Solubility: Practically insoluble in chlorofor ether, and cold water
Product Spec.:
95.0 ~ 101.5% Rutin NF11 (USP 32 Standard)
Product Introduction
Rutin, also called rutoside, quercetin-3-rutinoside and sophorin, is a citrus flavonoid glycoside found in the flower bud of Scphora japonica L, It is also present in many other plants and sometimes referred to as Vitamin P, although not strictly a vitamin.
Rutin is the glycoside between the flavonol quercetin and the disaccharide rutinose. Rutin can be created by bonding a disaccharide onto the hydroxyl group of Quercetin. Rutin (quercetin rutinoside), as well as quercitrin, is a glycoside of the flavonoid Quercetin. As such, the chemical structure of both is very similar, with the difference existing in the Hydroxyl functional group. Both quercetin and rutin are used in many countries as medications for blood vessel protection and are ingredients of numerous multivitamin preparations and herbal remedies.
| TEST | EP8 | RESULTS | Test Method |
| Appearance | Light greenish yellow powder | Complies | Visual |
| Identification | B.IR absorbance | Matching | IR |
| A.UV absorbance | Matching | UV | |
| C.TLC Examination | Matching | TLC | |
| D.Color reaction with Zn | Matching | Visual | |
| Particle size | 95% pass through sieve 80mesh | Complies | US Screen |
| Residual solvents | ≤2.0% | 0.06% | HPGC |
| Light absorbing impurities | Abs≤0.10 between 450-480nm | 0.05 | UV |
| Susbtance insoluble in methano | ≤3.0% | 0.80% | CP2010 |
| Impurity | |||
| A.Isoquercetin | ≤2.0% | 0.41% | HPLC |
| B.Kaempferol3-Rutinoside | ≤2.0% | 1.45% | HPLC |
| C.Quercetin | ≤2.0% | 0.04% | HPLC |
| Total Impurity | ≤4.0% | 3.31% | HPLC |
| Bulk density | ≥0.30gm/cc | 0.37gm/cc | CP2010 |
| Tapped density | ≥0.50gm/cc | 0.56gm/cc | CP2010 |
| Residual Solvents Methano | ≤0.3% | <0.3%<> | GC |
| Heavy metals | ≤10ppm | <10ppm<> | Visual Colorimetry |
| -Arsenic | ≤1ppm | <1ppm<> | AAS |
| -Mercury | ≤0.1ppm | <0.1ppm<> | AAS |
| -Cadmium | ≤1ppm | <1ppm<> | AAS |
| -Lead | ≤3ppm | <3ppm<> | AAS |
| Ash | ≤0.10% | 0.08% | CP2010 |
| Loss on drying | 7.5%-9.5% | 8.60% | 105ºC/3h |
| Assay(on dry basis) | 95.0%-101.0% | 99.94% | UV |
| Microbiological test: | |||
| Total plate count | ≤1000cfu/g | 100cfu/g | AOAC966.23 |
| Mildew&Yeast | ≤100cfu/g | 20cfu/g | FDABAM8th |
| E.Coli | Negative | Negative | FDABAM8th |
| Salmonella | Negative | Negative | FDABAM8th |
| Coliforms | ≤10cfu/g | <10cfu> | AOAC911.14 |
| Enterobacteria | Negative | Negative | FDABAM8th |
| Resticide Screen | Meets the requirements of EP 8. | ||
| GMO/BSE Status | Not genetically modified organism .Free of BSE | ||
| Storage | Store in tight containers,in a cool dry area. | ||
Function & Application
1. Rutin inhibits platelet aggregation, as well as decreasing capillary permeability, making the blood thinner and improving circulation.
2. Rutin has anti-inflammatory activity.
3. Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into a sugar alcohol called sorbitol.
4. Rutin also strengthens the capillaries, and, therefore, can reduce the symptoms of haemophilia. It also may help to prevent a common unpleasant-looking venous edema of the legs. Rutin, as ferulic acid, can reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease.
5. There is also some evidence that Rutin can be used to treat hemorrhoids, varicosis, and microangiopathy.
6. Rutin is also an antioxidant, along with quercetin, acacetin, morin, hispidulin, hesperidin, and naringin; it was found to be the strongest.
7. Hydroxyethylrutosides, synthetic hydroxyethyl acetylations of rutin, are used in the treatment of chronic venous insufficiency.
Applications
1. Functional food and food additive
2. Pharmaceutical stuff
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