| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Factory Price API Mosapride Citrate Dihydrate Raw Powder CAS 156925-25-6
| Product name:Mosapride citrate dihydrate |
| Other Name:Mosapride Citrate |
| Appearance:White Powder |
| CAS:156925-25-6 |
| M.F:C27H37ClFN3O12 |
| M W:650.047 |
| Grade:Pharmaceutical Grade |
| Specification:99% |
Citrate moser will benefit (Mosapride Citrate, MC) promote power for the fourth generation of gastrointestinal medicine, is a potent selectivity of 5 - HT4 agonists, through 5 - excited myenteric plexus HT4 receptors, stimulate acetylcholine release, strengthen the stomach and duodenum movement, clinical used in functional dyspepsia, gastroesophageal reflux disease, diabetic gastroparesis, partial nephrectomy in patients with gastric diseases such as gastric dysfunction. Common adverse reactions include diarrhea, abdominal pain, dry mouth, rash, tiredness and headache. At present, its market products are only tablets, dispersible tablets, capsules and other oral dosage forms.
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:Moxapride citrate is similar to cisapride, both of which are benzodiamide derivatives. By stimulating 5-ht4 receptors in intestinal muscle plexus, moxapride citrate can increase the release of acetylcholine in nerve endings and promote gastrointestinal motility and gastric empty.it has the advantages of strong receptor selectivity, good pharmacokinetics, selective action on digestive tract and small dose. Electrophysiological studies have shown that it has no effect on extending the action potential duration of isolated ventricular muscle and bradycardia fibers, so it has better safety.
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