| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Pharmaceutical Chemical Antihistamine Raw Powder CAS 147-24-0 Diphenhydramine Hydrochloride
| Product name:Diphenhydramine Hydrochloride |
| Other Name: diphenhydraMine-N-oxide hydrochloride,Diphenhydramine hcl |
| Appearance:White Powder |
| CAS:147-24-0 |
| M.F:C17H22ClNO |
| M.W.:291.82 |
| Specification:99% |
Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic. Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either contains 0.1 mg/mL benzethonium chloride as a germicidal agent.
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Diphenhydramine HCl is used for allergies of skin and mucous membranes, such as urticaria and angioneurotic edema.
Diphenhydramine HCl is also effective against bug bites and contact dermatitis.
Diphenhydramine HCl has a strong antiemesis effect in the prevention and treatment of motion sickness.
Diphenhydramine HCl is used to treat coughs due to colds or allergies.
Diphenhydramine HCl is used for Parkinson's disease and extrapyramidal symptoms.
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