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| Powder: | Yes |
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Pharmaceutical Grade Raw powder 99% 7-Ethyl-10-Hydroxycamptothecin CAS 119577-28-5
| Product Name | 10-HYDROXYCAMPTOTHECIN / 7-Ethyl-10-hydroxycaMptothecin |
| CAS NO. | 130194-92-2 |
| Appearance | White Powder |
| Purity | 99% |
| Density | 1.60 g/cm3 (20 ºC 760 Torr) |
| Application | Pharmaceutical raw materials; camptothecin series; Chinese herbal medicine ingredients; pharmaceutical intermediates |
Camptothecin is an alkaloid derived from the chinese tree Camptotheca acuminata Decne.
Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,
by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately
causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited
remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.
If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein
cannot be synthesized, it ultimately causes cell death. Application of
camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous
therapy such as topotecan and irinotecan while others have been obtained satisfying
curative effects in clinic.
1) Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,
by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately
causes tumor cell death.
2) In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.
If the chromosomes cannot be unwound, transcription of DNA message cannot occur and
the protein cannot be synthesized, it ultimately causes cell death.
3) Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. 4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy
such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Xi'an Biohorlden Industry&Trade Co.,Ltd is a national key high-tech enterprise,which mainly specializes in the R&D, operation and production of pharmaceuticals,and intermediates.Our company is situated in E&T development zone,xi'an city shaanxi,it is easy of access. Our company has independent R&D center,raw material synthesis workshop, has advanced quality instruments and equipmentm,several product patents there are 15 experts in our research team.We insist in innovation and produce high quality products.
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