Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product name:Pyrimethamine |
Other Name:Pyrimethamine |
Appearance:White Powder |
CAS:58-14-0 |
M.F:C12H13ClN4 |
M W:248.71 |
Grade:Pharmaceutical Grade |
Specification:99% |
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tems |
Standards |
Results |
Physical Analysis |
||
Description |
White Powder | Complies |
Assay |
99% | 99.6% |
Mesh Size |
100 % pass 80 mesh | Complies |
Ash |
≤ 5.0% | 2.85% |
Loss on Drying |
≤ 5.0% | 2.65% |
Chemical Analysis |
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Heavy Metal |
≤ 10.0 mg/kg |
Complies |
Pb |
≤ 2.0 mg/kg |
Complies |
As |
≤ 1.0 mg/kg | Complies |
Hg |
≤ 0.1mg/kg | Complies |
Microbiological Analysis |
||
Residue of Pesticide |
Negative | Negative |
Total Plate Count |
≤ 1000cfu/g | Complies |
Yeast&Mold |
≤ 100cfu/g | Complies |
E.coil |
Negative |
Negative |
Salmonella |
Negative |
Negative |
Function:
Pyrimethamine (RP4753) can interfere with the synthesis of tetrahydrofolate by inhibiting dihydrofolate reductase (DHFR), which can act on protozoan infections.
This product can inhibit the dihydrofolate reductase of the plasmodium, thereby interfering with the normal generation of folic acid of the plasmodium. It is effective in the early stage of falciparum malaria and Plasmodium vivax erythrocytes. It is often used as a pathogenic preventive drug. In addition, it can also inhibit the development of malaria parasites in mosquitoes, so it can block transmission. It is clinically used to prevent malaria and anti-relapse treatment during resting period.