Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product name:Minocycline hydrochloride |
Other Name: Minocycline Hcl,[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxaMide Monohydrochloride |
Appearance:Light Yellow Powder |
CAS:13614-98-7 |
M.F:C23H28ClN3O7 |
M W:493.94 |
Grade:Pharmaceutical Grade |
Specification:99% |
Minocycline hydrochloride is a broad-spectrum antibiotic. It is effective against Staphylococcus aureus that is sensitive or resistant to tetracycline; it is effective against Staphylococcus viridans, Actinomyces stellate, Pneumococcus and bacterial-like microorganisms, and Neisseria gonorrhoeae. The effect is slightly stronger than other tetracyclines, and the antibacterial strength against Escherichia coli, Proteus, Salmonella, Shigella, Klebsiella, and Pseudomonas is similar to that of tetracyclines. Its hydrochloride is commonly used, which is yellow crystalline powder, odorless, bitter in taste, and can cause deterioration when exposed to light. It is soluble in water, slightly soluble in ethanol, and easily soluble in alkali metal hydroxide or carbonate solution.
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ITEM | SPECIFICATION | RESULT | METHOD |
Appearance | Light Yellow powder, neutral odor, highly hygroscopic | Conforms | Visual |
Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
Specific Optical | -2.4°~ -2.8° | -2.72° | |
Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
pH | 4.5~7.0 | 5.10 | |
Related substance | Spot not bigger than standard solution spot | No spot | TLC |
Water Content | ≤2% | 0.26% | KF |
Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function: