| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Pharmaceutical Grade Raw Amphotericin B Powder CAS 1397-89-3 99% Purity Amphotericin B
| Product name:Amphotericin B |
| Other Name:Fungizone |
| Appearance:Yellow Powder |
| CAS:1397-89-3 |
| M.F:C47H73NO17 |
| M W:924.08 |
| Grade:Pharmaceutical Grade |
| Specification:99% |
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | Yellow powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Amphotericin B is the polyene Antifungal antibiotic classes, through the influence of cell membrane permeability to play the role of inhibition of fungal growth. Clinically for the treatment of serious internal organs or body of deep fungal infection.
Application:
1. One of the main intravenous uses is in treating various systemic fungal infections (e.g., in critically ill, comorbidly infected or immunocompromised patients), including cryptococcal meningitis.
2. Amphotericin B is also commonly used in tissue culture to prevent fungi from contaminating cell cultures. It is usually sold in a concentrated solution, either on its own or in combination with the antibiotics penicillin and streptomycin.Antiprotozoan
3. Another IV use is as a drug of last resort in otherwise-untreatable parasitic protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis.
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