| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Pharmaceutical Raw Material Capecitabine Powder Capecitabine Powder Capecitabine
| Product name:Capecitabine Powder |
| Other Name: Capecitabine,anoralprodrugthatisconvertedtoitsactivemetabolite,5-FU,bythymidinephosphorylase |
| Appearance:White Powder |
| CAS:154361-50-9 |
| M.F:C15H22FN3O6 |
| M.W.:359.35 |
| Specification:99% |
Capecitabine is rapidly absorbed by the intestinal mucosa after oral administration, and then converted into an inactive intermediate 5'-deoxy-5' fluorocytidine in the liver by carboxyl esterase, followed by cytidine removal from liver and tumor tissues. The action of the aminoase is converted to 5'-deoxy-5' fluorouridine and finally catalyzed by thymidine phosphorylase to fluorouracil (5-FU) in tumor tissues.
Clinical studies have shown that the concentration of 5-FU in tumor tissue after oral administration is significantly higher than that of blood and muscle. The efficacy of tumors in a variety of animals was significantly higher than 5-FU. This product has synergistic effects with a variety of anti-tumor drugs.
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
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