Pharmaceutical Raw Material USP Grade Clobetasol Propionate Powder

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: bio
• Certification: GMP, ISO 9001, USP, BP
• State: Powder
• Purity: >98%
• Product Name: Clobetasol Propionate
• C.a.S No: 25122-46-7
• Einecs No: 246-634-3
• Molecular Formula: C25h32clfo5
• Molecular Weight: 466.97
• Appearance: White Crystalline Powder
• Storage: Cool Dry Place
• Shelf Life: 2 Years
• Delivery Time: 3-7 Days
• Transport Package: Foil Bag/Drum
• Specification: 98%
• Trademark: Biohorlden
• Origin: China
• Production Capacity: 10000

Product Description

Pharmaceutical Raw Material USP Grade Clobetasol Propionate Powder
 

Name: Clobetasol propionate
C.A.S NO. : 25122-46-7
Synonyms: 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
EINECS NO.: 246-634-3
Molecular formula: C25H32ClFO5
Molecular weight : 466.97
Assay: 99%
Characteristic: White crystalline powder

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I of the corticosteroids,

making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, lichen sclerosus, and lichen planus.

Item	Specification	Results
Appearance	white to cream,crystalline powder	White crystalline powder
Identification (by IR)	Confirms to the CRS spectrum	Confirm
Melting point	Approximately 196ºC	196ºC
Specific rotation	+98°~+104°(dried substance)	+78.0°
Loss on drying	≤ 2.0%	0.2%
Residue on ignition	≤0.1%	0.04%
Heavy metals	≤20ppm	Confirm
Related substances(by HPLC)	Any impurity≤1.0% Total impurities≤2.5%	0.15% 0.15%
Assay(by HPLC)	Contains 97.0% to 102.0% of C25H32ClFO5 Calculated on dried basis	100.4%
Residual solvents	Ethanol ≤ 3000ppm Acetone ≤ 500ppm Pyridine ≤ 100ppm N,N-Dimethylformamide ≤ 100ppm	269ppm <4ppm <3ppm <10ppm

Function
 

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.

2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins.

 

 

Xi'an Biohorlden Industry&Trade Co.,Ltd is a national key high-tech enterprise,which mainly specializes in the R&D, operation and production of pharmaceuticals,and intermediates.Our company is situated in E&T development zone,xi'an city shaanxi,it is easy of access. Our company has independent R&D center,raw material synthesis workshop, has advanced quality instruments and equipmentm,several product patents there are 15 experts in our research team.We insist in innovation and produce high quality products.

1.Are you a manufacturer or trade company?

We are a professional manufacturer.

2.What's your payment terms?

Standard terms: T/T in advance and Western Union.

Also L/C at sight is acceptable for large amount.

3.What's your shipping time?

We have a large stock, which means we can deliver the goods to you immediately.

4.How do you ensure the quality of your products?

Strict QC with 6 steps testing from raw material purchase to finished product.

5.How do you ship the order normally?

For large qty order,ship the goods by sea.

For small qty order, by air or express. We supply optional express for you, including DHL,FEDEX,UPS,TXT,EMS,and so on.

6.What's your loading port?

Usually Shanghai, Qingdao, Tianjin, Guangzhou