Customization: | Available |
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Powder: | Yes |
Customized: | Non-Customized |
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Pharmaceutical Grade High quality 5-Fluorouracil price cas 51-21-8 Raw powder 99% Purity 5-Fluorouracil
Common Name | 5-Fluorouracil | ||
---|---|---|---|
CAS Number | 51-21-8 | Molecular Weight | 130.077 |
Density | 1.7±0.1 g/cm3 | Boiling Point | 401.4±48.0 °C at 760 mmHg |
Molecular Formula | C4H3FN2O2 | Melting Point | 282-286 °C (dec.)(lit.) |
MSDS | ChineseUSA | Flash Point | 196.5±29.6 °C |
Item | Specification | Result |
Appearance | white to off-white powder | Complies |
Related substance (HPLC) | Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
Odor | Characteristic | Complies |
Assay | 99% | 99.8% |
Sieve analysis | 100% pass 80 mesh | Complies |
Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
Heavy Metal | <10ppm | Complies |
As | <0.1ppm | 0.05ppm |
Pb | <0.1ppm | 0.05ppm |
Cd | <0.1ppm | 0.05ppm |
Residual Solvents | <100ppm | Complies |
5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
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