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Veterinary Medicine Lincomycin/Lincomycin Hydrochloride
Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis.A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7-hydroxy group with a chlorine atom with inversion of chirality.
Product Name: lincomycin
CAS NO: 154-21-2
Molecular Formula: C18H35ClN2O6S
Molecular Weight: 442.998
Appearance: White crystalline powder
ITEMS | SPECIFICATION | RESULTS |
Appearance | White or almost white crystalline powder | Conforms |
Solubility | Insoluble in water, very soluble in methanol, chloroform, freely soluble in anhydrous alcohol and ethyl acetate. |
Conforms |
E1%1cm | (458--486) | Conforms |
Melting Range | (5255) | 53-54 |
Loss on drying | No more than 0.1% | 0.1% |
Residue on lgnition | No more than 0.1% | 0.04% |
Heavy metals | No more than 10ppm | Conforms |
Impurities (HPLC) | No more than 0.8% | 0.5% |
Residue Solvents (GC) |
Hexane≤0.029% | Conforms |
Methanol≤0.3% | Conforms | |
Assay (HPLC) | Conforms | |
Assay (HPLC) | No less than 98.5% on the dried basis |
Lincomycin kills bacteria by interfering with the ability of bacteria to produce important proteins necessary for them to survive. Lincomycin is effective against many types of bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Propionibacterium acnes, and others. Use of lincomycin is reserved for penicillin-allergic patients or when penicillin-based treatment is not appropriate. This antibiotic should only be used to treat serious infections because of rare but sometimes fatal intestinal problems have occurred. The specific infections for which LINCOCIN is used include: Ear, throat and lung infections; Skin infections; Bone and joint infections;And infections of the blood. LINCOCIN will not work against viral infections such as colds or flu.