| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product name: Citicoline Powder |
| Other Name:CITICOLINE;CYTIDINE 5'-DIPHOSPHOCHOLINE;CYTIDINE DIPHOSPHATE CHOLINE;CDP-CHOLINE;cdp-cholin;cdp-colina;cereb;choline,hydroxide,5'-esterwithcytidine5'-(trihydrogenpyrophosphate) |
| Appearance:White Powder |
| CAS NO.: 987-78-0 |
| M.F.: C14H26N4O11P2 |
| M.W.: 488.32 |
| Specification:99% |
Citicoline Sodium, also known as cytidine diphosphate-choline (CDP-Choline) & cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline. Studies suggest that CDP-choline supplements increase dopamine receptor densities, and suggest that CDP choline supplementation helps prevent memory impairment resulting from poor environmental conditions.Preliminary research has found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder.
| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
1. Citicoline Sodium is a brain chemical that occurs naturally in the body.
2. As a medicine, Citicoline is taken by mouth as a supplement or given by IV or as a shot.
3. Citicoline Sodium is used for Alzheimer's disease and other types of dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson's disease, and glaucoma.
Citicoline(CDP Choline) is a precursor of phosphatidylcholine. As a type of phospholipid, phosphatidylcholine is an important component of cell membranes. When taken orally, Citicoline(CDP Choline) is metabolized to yield the free nucleotide,uridine and choline. Uridine and choline cross the blood-brain barrier,become incorporated into brain membrane phospholipids and increase the production of neurotransmitters in the central nervous system, including the synthesis of acetylcholine, noradrenaline and dopamine. In the brain, Citicoline(CDP Choline) stabilizes the cell membranes and inhibits the formation of cytotoxic free fatty acids.
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