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Powder: | Yes |
Customized: | Non-Customized |
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Product Name: CYCLAZOSIN HYDROCHLORIDE
Other Name: Cyclazosin Hcl
CAS: 146929-33-1
MF: C23H27N5O4
MW: 473.95
Appearance:White crystal powder
Purity:99%
CYCLAZOSIN HYDROCHLORIDE is A hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride.
Cyclazosin hydrochloride is a hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride. It has a role as an alpha1B-adrenoceptor antagonist. It contains a cyclazosin.
Physical&Chemical Control | ||
ITEM | SPECIFICATION | RESULTS |
Appearance | Fine powder | Complies |
Colorl | White | Complies |
Odor&Taste | Characteristic | Complies |
Assay | ≥99% | 99.53% |
Heavy Metals | ≤10ppm | Complies |
Pb |
≤2ppm |
Complies |
As |
≤2ppm |
Complies |
Hg |
≤1ppm |
Complies |
Cad |
≤1ppm |
Complies |
Sulphates |
≤300ppm |
Complies |
Ammonium | ≤200ppm | Complies |
Iron | ≤10ppm | Complies |
Microbiological Control |
In Vivo Use Guide
The putative a1B-adrenoceptor antagonist cyclazosin (1mg/kg) in vehicle experiments did not significantly alter the body temperature when compared to vehicle group. The pretreatment of mice with cyclazosin significantly altered the effect of MDMA on core body temperature
Route of Administration: Topical
In Vitro Use Guide
Sections of the abdominal aorta, obtained from adult female New Zealand rabbits, were treated with agonists and antagonists of adrenergic receptors. Administration of cyclazosin at a dose of 0.002 μM caused a decrease in the muscle tonus of -0.49 ± 0.10 mN. After blockade of the α1B-adrenergic receptor by 0.02 mkM cyclazosin, the administration of 0.05 μM phenylephrine resulted in an increase of the aortic muscle tonus of 1.49 ± 0.14 mN.
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IDRA 21 | 22503-72-6 |
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aniracetam | 72432-10-1 |
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