| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, ISO 9001, USP, BP |
| Suitable for: | Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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| Product name: Acyclovir Powder |
| Other Name:acycloguanosine,: 1,9-dihydro-2-amino-9-((2-hydroxyethoxy)methyl)-6h-purin-6-on;2-amino-1, |
| Appearance:White Powder |
| CAS NO.: 59277-89-3 |
| M.F.: C8H11N5O3 |
| M.W.:225.2 |
| Specification:99% |
Acyclovir (ACV), also known as acycloguano-sine. It is primarily used for the treatment of herpes simplex infections, chickenpox, and shingles. It can be taken by mouth, applied as a cream.
Application of Acyclovir Acyclovir, also known as acyclovir, is used to treat HSV and VZV infections. Function of Acyclovir Acyclovir is indicated for the treatment of HSV and VZV infections, including: Genital herpes simplex (treatment and prophylaxis) Herpes simplex labialis (cold sores) Herpes zoster (shingles) Acute chickenpox in immunocompromised patients Herpes simplex encephalitis Acute mucocutaneous HSV infections in immunocompromised patients Herpes simplex keratitis (ocular herpes) Herpes simplex blepharitis (not to be mistaken with ocular herpes) Prophylaxis against herpesviruses in immunocom-promised patients (such as patients undergoing cancer chemotherapy).
| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Acyclovir, 9-[2-(hydroxyethoxy)methyl]-9H-guanine (Zovirax),is the most effective of a series of acyclic nucleosidesthat possess antiviral activity. In contrast with true nucleosidesthat have a ribose or a deoxyribose sugar attached to apurine or a pyrimidine base, the group attached to the basein acyclovir is similar to an open chain sugar, albeit lackingin hydroxyl groups. The clinically useful antiviral spectrumof acyclovir is limited to herpesviruses. It is most active (invitro) against HSV type 1, about two times less against HSVtype 2, and 10 times less potent against varicella-zostervirus (VZV).
Orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral; hypnotic.
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